In what may provide important tips for designing an effective AIDS vaccine, scientists have found that two simple changes in its outer envelope protein may render the AIDS virus vulnerable to attack by the immune system.
The study revealed that the virus contains mutation in four amino acids in the envelope protein. Two of such amino acids, when introduced into unrelated strains of HIV in the laboratory, provided sensitivity to inactivation by a number of antibodies produced in people infected with HIV.
The researchers believe that such mutations may cause a change in the overall structure of the envelope protein, which results in exposure to the immune system of regions that are normally hidden.
Vaccines containing envelope proteins that include such mutations might be able to stimulate an antibody response that would protect against infection with HIV, should further research confirms this idea.
The new findings have been published in PLoS Medicine.
The study revealed that the virus contains mutation in four amino acids in the envelope protein. Two of such amino acids, when introduced into unrelated strains of HIV in the laboratory, provided sensitivity to inactivation by a number of antibodies produced in people infected with HIV.
The researchers believe that such mutations may cause a change in the overall structure of the envelope protein, which results in exposure to the immune system of regions that are normally hidden.
Vaccines containing envelope proteins that include such mutations might be able to stimulate an antibody response that would protect against infection with HIV, should further research confirms this idea.
The new findings have been published in PLoS Medicine.
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